Pre-clinical
Indications

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RECCE® 327

M. abscessus
Mycobacteroides abscessus (M. abscessus) is a species of rapidly growing, multi-drug resistant nontuberculous mycobacteria (NTM) that commonly cause chronic lung infection and skin and soft tissue infection. While it has a relatively low incidence rate (< 1/100,000), it is particularly prevalent and more difficult to treat in immunocompromised patients or patients with underlying lung diseases, such as cystic fibrosis. M. abscessus is generally found in water, soil, and dust and has been known to contaminate prescriptions and medical equipment. High five-year mortality rates of approximately 47% have been observed in strains that exhibit resistance to macrolides, a class of antibiotics.
A. baumannii
Study Details: A recent study conducted at Recce’s Anti-Infective Research Unit within MCRI demonstrated significant intracellular bactericidal activity of R327 against multidrug-resistant Acinetobacter baumannii (A. baumannii), a WHO critical-priority pathogen.
Results: R327 achieved a >6.5 log reduction (99.9999%) in intracellular bacterial burden in human skin cells within 1 hour, reducing bacteria to below the limit of quantification (BLOQ).
Bacterial Sinusitis
Anti-Infective Research (AIR) Unit
