Burn Wound Infections

Burn Wound
Infections

RECCE® 327 Topical

RECCE® 327 (R327) as a topical formulation is being studied for efficacy on a broad range of bacterial wounds, burns and skin infections.

Overview

Aggressive infection is the leading cause of death and morbidity of burn wound sufferers. The most relevant and dangerous of burn wound infections are those involving Staphylococcus aureus (S. aureus), a Gram-positive bacteria located on the skin and mucous membranes (most often the nasal area).

S. aureus is the most dangerous of all of the many common staphylococcal bacteria. This bacteria often causes skin infections; however, it can also cause pneumonia, bone infections, meningitis and other invasive infections.

With the emergence of multi-drug resistant strains such as Methicillin-resistant Staphylococcus aureus (MRSA or ‘golden staph’), effective treatment options are often lacking. Patients with MRSA have significantly longer hospital stays and are estimated to be 64% more likely to die than people with a non-resistant form of the infection.

Burn Wound Infection Cases and Fatalities by Geographical Area

Worldwide

11 million

cases requiring medical intervention annually

300,000

deaths annually

USA

500,000

burn wound injuries requiring medical intervention annually

Europe

710 million

European Burn Care market calculated at 530 million annually in 2020 expected to grow to 710 million by end of 2025

Australia

50,000

Approximately 50,000 burn-related hospital admissions annually

Advancing the Treatment of Burn Wound Infections

Recce Pharmaceuticals is pioneering the development of RECCE® 327 Gel (R327G), a novel synthetic anti-infective designed to revolutionise the treatment of burn wound infections. Our innovative approach addresses both the acute phase of burn injuries and the prevention of downstream complications such as sepsis, a critical concern in both military and civilian settings.

US Department of Defense Grant: Accelerating Breakthroughs

Recce has been awarded US$2 million (~ A$3 million) in funding from the US Department of Defense’s Congressionally Directed Medical Research Programs (CDMRP) under the Military Burn Research Program (MBRP). This prestigious grant highlights the recognition of R327G’s potential in the management of burn wound infections, particularly in military environments where rapid, effective treatment is vital.

Key Highlights:

US$2 Million Funding: Supporting the development and evaluation of R327G for acute burn wound infections.
Military-Grade Application: Designed for use in far-forward military settings, enabling rapid treatment at the point of injury.
Potential to Replace Traditional Antimicrobials: Aiming to outperform current antimicrobial dressings and topical agents used in military healthcare.
Exploratory Phase I/II Study where five patients were treated for up to two weeks, with results showing R327G was safe and well-tolerated.
Rat Thermal Wound Infection Model: Demonstrated significant antibacterial activity against MRSA, reduced bacterial load and higher percentage of wound closure with increasing doses of R327 compared to Soframycin.

Efficacy Against High-Priority Biothreat Pathogens

In parallel, Recce has entered into an active research partnership with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) to test R327 against high-priority biothreat pathogens, reinforcing the platform’s dual-use potential in both combat and biodefense contexts.

Highlighting the growing recognition of its innovation, Recce was also accepted for a poster presentation and abstract at MHSRS 2025 (Military Health System Research Symposium), the premier U.S. forum for military medical research. This milestone marks further validation of R327G’s potential to transform infection control in military medicine.

ASX: RCE

$0.0

ASX: RCE

$0.0

ASX: RCE

$0.0